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Although the opiate receptor relies on G protein coupling for signal transduction, this receptor was identified to utilize arrestin activation for internalization in the receptor. If not, the receptor promoted no other signali… Read More

Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors while in the central nervous technique, conolidine modulates alternate molecular… Read More

Most not long ago, it has been discovered that conolidine and the above derivatives act over the atypical chemokine receptor 3 (ACKR3. Expressed in similar areas as classical opioid receptors, it binds to a big range of endoge… Read More

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